Detalhe da pesquisa
1.
Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Nature
; 604(7904): 160-166, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35355011
2.
Nanoscale synthesis and affinity ranking.
Nature
; 557(7704): 228-232, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29686415
3.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Bioorg Med Chem
; 26(10): 2807-2815, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29598901
4.
Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
J Pharmacol Exp Ther
; 361(2): 229-244, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193636
5.
Exploring new targets and chemical space with affinity selection-mass spectrometry.
Nat Rev Chem
; 5(1): 62-71, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37118102
6.
Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space.
SLAS Discov
; 25(4): 384-396, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31701793
7.
An orally available non-nucleotide STING agonist with antitumor activity.
Science
; 369(6506)2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32820094
8.
Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.
ACS Chem Biol
; 13(3): 820-831, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29412640
9.
Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.
Antivir Chem Chemother
; 18(3): 163-7, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17626600
10.
Solid phase extraction as a faster alternative to HPLC: application to MS analysis of metabolic stability samples.
J Pharm Sci
; 96(6): 1619-24, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17094126
11.
Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.
J Med Chem
; 59(5): 1818-29, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26871940
12.
Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
J Biomol Screen
; 21(6): 608-19, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26969322
13.
A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen.
J Biomol Screen
; 9(1): 3-11, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15006143
14.
Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.
Bioorg Med Chem Lett
; 17(15): 4303-7, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17532216
15.
Thienopyridine urea inhibitors of KDR kinase.
Bioorg Med Chem Lett
; 17(5): 1246-9, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17188869
16.
Mechanism of action of a novel series of naphthyridine-type ribosome inhibitors: enhancement of tRNA footprinting at the decoding site of 16S rRNA.
Antimicrob Agents Chemother
; 49(5): 1890-7, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15855511
17.
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives.
Bioorg Med Chem Lett
; 15(11): 2716-9, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911248
18.
Automatic mass spectrometry method development for drug discovery: application in metabolic stability assays.
Rapid Commun Mass Spectrom
; 18(24): 3105-12, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15565734
19.
SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes.
J Am Chem Soc
; 126(8): 2390-8, 2004 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14982445
20.
Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.
Bioorg Med Chem Lett
; 14(12): 3299-302, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15149694